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Research
Outline
There are three major research aim as follows.
① Isolation and Cultivation of Microbes
Microbes such as actinomycete and fungi are isolated from various environments (soil, marine, hot spring, insect etc) in Japan, and a one-of-a-kind of microbial library has been constructed, which is useful for discovery of new baioactive compounds.
Sampling
Isolation
Cultivation
Library of culture broth
② Screening for Discovery of New Bioactive Compounds
Our research group has focused on discovery of new compounds active against lifestyle-related diseases, cancer and infection diseases. Unique assay systems mimic to the disorders are constructed using special cells, insects and animals. Based on activity-guided/analysis-guided purification of new compounds from microbial cultures is carried out using various purificationtechniques such as extraction, column chromatography, HPLC and so on. Finally, the structures are elucidated using various spectroscopic analysis such as Mass NMR, UV, IR and CD spectra.
Anti-microbial agents
Regulators of
lipid metabolism
Regulators of
bone metabolism
Enhancers of anti-microbial clinical drugs
We have other various assay systems and search for bioactive compounds.
③ Study on Mechanism of Action
Mechanisms of action of new bioactive compounds is studied by biochemical and genetical techniques using labeled compounds, biotinyl compounds, CETSA, DARTS and so on.
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